Arquivos Repositório Covid-19 - Página 5 de 41

12/09/2022

Research and development of Chinese anti-COVID-19 drugs

Abstract

The outbreak and spread of coronavirus disease 2019 (COVID-19) highlighted the importance and urgency of the research and development of therapeutic...

12/09/2022

An insight into the placental growth factor (PlGf)/angii axis in Covid-19: a detrimental intersection

ABSTRACT

12/09/2022

Withholding methotrexate after vaccination with ChAdOx1 nCov19 in patients with rheumatoid or psoriatic arthritis in India (MIVAC I and II): results of two, parallel, assessor-masked, randomised controlled trials

Summary

Background

There is a necessity for an optimal COVID-19 vaccination strategy for vulnerable population groups, including people with autoimmune...

12/09/2022

Molecular insights into the interaction of apo-lactoferrin with the receptor binding domain of the SARS-CoV-2 spike protein: a molecular dynamics simulation study

LF is a bioactive protein, derived from colostrum and milk that has been found to possess various immunomodulatory, iron chelating,...

09/09/2022

Factors influencing neutralizing antibody titers elicited by coronavirus disease 2019 vaccines

The World Health Organization has highlighted the importance of an international standard (IS) for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)...

09/09/2022

A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

Abstract

The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To...

06/09/2022

Methylprednisolone pulse therapy for critically ill patients with coronavirus disease 2019: A single-center retrospective observational study

This study compared the clinical outcomes of critically ill patients with coronavirus disease (COVID-19) pneumonia treated with high-dose methylprednisolone and...

05/09/2022

Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial

Background

Neutrophil serine proteases are involved in the pathogenesis of COVID-19 and increased serine protease activity has been reported in...

05/09/2022

Immunogenicity and safety of an inactivated whole-virus COVID-19 vaccine (VLA2001) compared with the adenoviral vector vaccine ChAdOx1-S in adults in the UK (COV-COMPARE): interim analysis of a randomised, controlled, phase 3, immunobridging trial

Summary

Background

The Valneva COVID-19 vaccine (VLA2001; Valneva Austria, Vienna, Austria) is an inactivated whole-virus, adjuvanted SARS-CoV-2 vaccine. We aimed...

03/09/2022

Computational screening for investigating the synergistic regulatory potential of drugs and phytochemicals in combination with 2-deoxy-D-glucose against SARS-CoV-2

Abstract

COVID-19 disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was declared a global pandemic by the World...

01/09/2022

Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge

BACKGROUND

The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-risk, unvaccinated patients infected with the B.1.617.2 (delta) variant...

31/08/2022

Covid-19 Vaccines — Immunity, Variants, Boosters

he coronavirus disease 2019 (Covid-19) pandemic has claimed an estimated 15 million lives, including more than 1 million lives in...