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Repositório Covid-19

1 semana atrás

Severe COVID-19 during pregnancy treated with pulse corticosteroid therapy and mid-trimester termination: A case report

At the early stage of the pandemic, severe COVID-19 was thought to be rare among pregnant women. However, cumulating data...

1 semana atrás

Identifying absorbable bioactive constituents of Yupingfeng Powder acting on COVID-19 through integration of UPLC-Q/TOF-MS and network pharmacology analysis

Yupingfeng Powder (YPF), a kind of preventative patent medicine, is chosen for treatment of coronavirus disease 2019 (COVID-19) due to...

1 semana atrás

Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis

In May, 2021, the delta (B.1.617.2) SARS-CoV-2 variant became dominant in the UK, superseded by the omicron (B.1.1.529) variant in...

1 semana atrás

Stapled peptides as potential inhibitors of SARS-CoV-2 binding to the hACE2 receptor

Stapled peptides are synthetic peptidomimetics of bioactive sites in folded proteins which carry chemical links, introduced during peptide synthesis, designed...

1 semana atrás

Monoclonal antibody therapies in the management of SARS-CoV-2 infection

Neutralizing antibodies (NAbs) that target key domains of the spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may...

1 semana atrás

Genome-Wide Characterization of SARS-CoV-2 Cytopathogenic Proteins in the Search of Antiviral Targets

Therapeutic inhibition of critical viral functions is important for curtailing coronavirus disease 2019 (COVID-19). We sought to identify antiviral targets...

1 semana atrás

Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) extensively N-glycosylates its spike proteins, which are necessary for host cell invasion and the...

1 semana atrás

The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics

There is an unmet need for preclinical models to understand the pathogenesis of human respiratory viruses and predict responsiveness to...

1 semana atrás

Human/SARS-CoV-2 genome-scale metabolic modeling to discover potential antiviral targets for COVID-19

Coronavirus disease 2019 (COVID-19) has caused a substantial increase in mortality and economic and social disruption. The absence of US...

1 semana atrás

Molecular docking studies of phytochemicals from Terminalia chebula for identification of potential multi-target inhibitors of SARS-CoV-2 proteins

The COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a global pandemic claiming more than...

1 semana atrás

Bat coronaviruses related to SARS-CoV-2 and infectious for human cells

The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV-2-related viruses in Asian Rhinolophus bats1,2,3,4, including the closest virus...

1 semana atrás

Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection

The duration and effectiveness of immunity from infection with and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are...

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