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CONTATO

Repositório Covid-19

04/10/2022

Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome

Coronavirus disease 2019 (COVID-19) is a highly infectious respiratory disease caused by a severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). SARS-CoV-2 infection...

03/10/2022

Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic....

03/10/2022

Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2

ABSTRACT

Three directly acting antivirals (DAAs) demonstrated substantial reduction in COVID-19 hospitalizations and deaths in clinical trials. However, these agents...

03/10/2022

Low-dose versus high-dose dexamethasone for hospitalized patients with COVID-19 pneumonia: A randomized clinical trial

Abstract

Background

Dexamethasone 6 mg daily for 10 days is the recommended treatment for patients with severe or critical coronavirus...

02/10/2022

Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study

Abstract

Vaccination constitutes the best long-term solution against Coronavirus Disease-2019; however, vaccine-derived immunity may not protect all groups equally, and...

28/09/2022

Robust therapeutic effects on COVID-19 of novel small molecules: Alleviation of SARS-CoV-2 S protein induction of ACE2/TMPRSS2, NOX2/ROS, and MCP-1

While new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constantly emerge to prolong the pandemic of COVID-19, robust...

28/09/2022

A phylogenetic perspective of antiviral species of the genus Artemisia (Asteraceae-Anthemideae): A proposal of anti SARS-CoV-2 (COVID-19) candidate taxa

Abstract

Introduction

Different classes of disease-causing viruses are widely distributed universally. Plant-based medicines are anticipated to be effective cures for...

22/09/2022

Efficacy of Approved Versus Unapproved Vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Randomized Blinded Clinical Trials

Abstract

Background

21/09/2022

Effect of intravenous almitrine on intubation or mortality in patients with COVID-19 acute hypoxemic respiratory failure: A multicentre, randomised, double-blind, placebo-controlled trial

Summary

Background

Severe hypoxemia in patients with COVID-19 pneumonia might result from hypoxic pulmonary vasoconstriction, contributing to ventilation/perfusion (V/Q) mismatch....

21/09/2022

Common human genetic variants of APOE impact murine COVID-19 mortality

Abstract

Clinical outcomes of severe acute respiratory syndrome 2 (SARS-CoV-2) infection are highly heterogeneous, ranging from asymptomatic infection to lethal...

20/09/2022

Casirivimab/imdevimab treatment for outpatient COVID-19 during a SARS-CoV-2 B1.617.2 (Delta) surge at a community hospital

Abstract

Context

Vaccination status has been shown to be linked to patient-centered outcomes in those with COVID-19. However, minimal data...

19/09/2022

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Abstract

There is an outstanding need for broadly acting antiviral drugs to combat emerging viral diseases. Here, we report that...

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