The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance human-to-human transmission1,2. Although much effort has focused on...
Remdesivir improves clinical outcomes in patients hospitalized with moderate-to-severe coronavirus disease 2019 (Covid-19). Whether the use of remdesivir in symptomatic,...
The coronavirus disease 2019 (COVID-19) pandemic caused by the coronavirus—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause global...
Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are...
Treatments for coronavirus disease 2019, which iscaused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2), are urgently needed but remain limited. SARSCoV-2...