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CONTATO

Repositório Covid-19

16/07/2021

Development of alveolar and airway cells from human iPS cells: toward SARS-CoV-2 research and drug toxicity testing

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 enters host cells by binding with the...

15/07/2021

Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19

Patients with underlying medical conditions are at increased risk for severe coronavirus disease 2019 (Covid-19). Whereas vaccine-derived immunity develops over...

15/07/2021

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape1,2,3, have activity against diverse sarbecoviruses4,5,6,7, and be highly protective through viral...

13/07/2021

Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study

Development of an effective antiviral drug for Coronavirus Disease 2019 (COVID-19) is a global health priority. Although several candidate drugs...

13/07/2021

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

The emergency use authorization of two mRNA vaccines in less than a year from the emergence of SARS-CoV-2 represents a...

10/07/2021

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice

Improving clinical care for individuals infected with SARS-CoV-2 variants is a global health priority. Small-molecule antivirals like remdesivir (RDV) and...

08/07/2021

Potential therapeutic approaches for the early entry of SARS-CoV-2 by interrupting the interaction between the spike protein on SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2)

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread around the globe. At...

08/07/2021

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1,2,3,4,5. Since then, it has become dominant in some regions...

08/07/2021

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social...

07/07/2021

Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile

Mass vaccination campaigns to prevent coronavirus disease 2019 (Covid-19) are occurring in many countries; estimates of vaccine effectiveness are urgently...

07/07/2021

Antibody epitopes in vaccine-induced immune thrombotic thrombocytopenia

Vaccine-induced immune thrombotic thrombocytopaenia (VITT) is a rare adverse effect of COVID-19 adenoviral vector vaccines1,2,3. VITT resembles heparin-induced thrombocytopaenia (HIT)...

06/07/2021

The molecular dynamics of possible inhibitors for SARS-CoV-2

The novel coronavirus SARS-CoV-2, responsible for the present COVID-19 global pandemic, is known to bind to the angiotensin converting enzyme-2...

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