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Repositório Covid-19

03/08/2021

Anti-SARS-CoV-2 and anti-cytokine storm neutralizing antibody therapies against COVID-19: Update, challenges, and perspectives

Coronavirus disease 2019 (COVID-19) has been declared by the World Health Organization (WHO) as a pandemic since March 2020. This...

02/08/2021

NSAIDs and COVID-19: A Systematic Review and Meta-analysis

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been discouraged for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, fearing...

02/08/2021

S100A8 may govern hyper-inflammation in severe COVID-19

The coronavirus disease 2019 (COVID-19) pandemic threatens human species with mortality rate of roughly 2%. We can hardly predict the...

02/08/2021

SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies

COVID-19 pandemic has emerged as a result of infection by the deadly pathogenic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing...

02/08/2021

Elevated INR in a COVID-19 patient after concomitant administration of favipiravir and warfarin: A case report

Favipiravir is a promising treatment candidate for managing coronavirus disease 2019 (COVID-19). Warfarin has many drug interactions, but no interactions...

31/07/2021

Remdesivir for the treatment of COVID 19: review of the pharmacological properties, safety and clinical effectiveness

Remdesivir is a nucleoside analog that inhibits viral RNA replication by blocking RNA-dependent RNA polymerase. First developed and tested during...

30/07/2021

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

In the battle against COVID-19, drugs discovered in repurposing screens are of particular interest because these could be rapidly implemented...

29/07/2021

Antiviral drugs for coronavirus disease 2019 (COVID-19): a systematic review with network meta-analysis

To better inform clinical practice, we summarized the findings from randomized controlled trials (RCTs) of antivirals for COVID-19.

29/07/2021

Topological network based drug repurposing for coronavirus 2019

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has become the current health concern and...

29/07/2021

Synthesis and Identification of Novel Potential Molecules Against COVID-19 Main Protease Through Structure-Guided Virtual Screening Approach

The novel coronavirus disease that arises in the end of 2019 (COVID-19) in Wuhan, China, has rapidly spread over the...

29/07/2021

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global...

29/07/2021

A Novel Therapeutic Peptide Blocks SARS-CoV-2 Spike Protein Binding with Host Cell ACE2 Receptor

Coronavirus disease 2019 is a novel disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus. It was first...

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