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CONTATO

Notícias

12/08/2022

Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2

Abstract

The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently demands novel direct antiviral treatments. The main protease (Mpro)...

Repositório Covid-19
12/08/2022

PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19

Abstract

The ongoing COVID-19 pandemic has claimed more than 6 million lives and continues to test the world economy and...

Repositório Covid-19
12/08/2022

Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment

Abstract

Since December 2019, the coronavirus (COVID-19) pandemic has imposed huge burdens to the whole world, seriously affecting global economic...

Repositório Covid-19
12/08/2022

Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach

Abstract

Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both pro-inflammatory and anti-inflammatory activity, depending...

Repositório Covid-19
11/08/2022

Safety of COVID-19 vaccines in pregnancy: a Canadian National Vaccine Safety (CANVAS) network cohort study

Summary

Background

Pregnant individuals have been receiving COVID-19 vaccines following pre-authorisation clinical trials in non-pregnant people. This study aimed to...

Repositório Covid-19
11/08/2022

Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age

Abstract

BACKGROUND

Since it was first identified in early November 2021, the B.1.1.529 (omicron) variant of severe acute respiratory syndrome...

Repositório Covid-19
11/08/2022

Bio-Manguinhos/Fiocruz inicia o fornecimento de adalimumabe biossimilar ao Sistema Único de Saúde

Fruto de uma Parceria para o Desenvolvimento Produtivo (PDP), o medicamento adalimumabe começa a ser fornecido ao Sistema Único de...

Associado em foco
10/08/2022

Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trial

Summary

Background

Emerging SARS-CoV-2 variants and evidence of waning vaccine efficacy present substantial obstacles towards controlling the COVID-19 pandemic. Booster...

Repositório Covid-19
10/08/2022

Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trial

Summary

Background

Emerging SARS-CoV-2 variants and evidence of waning vaccine efficacy present substantial obstacles towards controlling the COVID-19 pandemic. Booster...

Repositório Covid-19
10/08/2022

Immunogenicity of ChAdOx1-nCoV-19 vaccine in solid malignancy patients by treatment regimen versus healthy controls: A prospective, multicenter observational study

Summary

Background

Limited data exists regarding the efficacy of ChAdOx1-nCoV-19 vaccine against Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) in...

Repositório Covid-19
09/08/2022

The mechanism of RNA capping by SARS-CoV-2

Abstract

The RNA genome of SARS-CoV-2 contains a 5′ cap that facilitates the translation of viral proteins, protection from exonucleases...

Repositório Covid-19
09/08/2022

Seasonal variation of the composition of essential oils from Piper cernuum Vell and Piper rivinoides Kunth, ADMET study, DFT calculations, molecular docking and dynamics studies of major components as potent inhibitors of the heterodimer methyltransferase complex NSP16-NSP10 SARS COV-2 protein

Abstract

Repositório Covid-19
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