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Severe hypoxemia in patients with COVID-19 pneumonia might result from hypoxic pulmonary vasoconstriction, contributing to ventilation/perfusion (V/Q) mismatch....

Repositório Covid-19

21/09/2022

Common human genetic variants of APOE impact murine COVID-19 mortality

Abstract

Clinical outcomes of severe acute respiratory syndrome 2 (SARS-CoV-2) infection are highly heterogeneous, ranging from asymptomatic infection to lethal...

Repositório Covid-19

20/09/2022

Casirivimab/imdevimab treatment for outpatient COVID-19 during a SARS-CoV-2 B1.617.2 (Delta) surge at a community hospital

Abstract

Context

Vaccination status has been shown to be linked to patient-centered outcomes in those with COVID-19. However, minimal data...

Repositório Covid-19

19/09/2022

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Abstract

There is an outstanding need for broadly acting antiviral drugs to combat emerging viral diseases. Here, we report that...

Repositório Covid-19

19/09/2022

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

Significance

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requires fusion of viral and host membranes, mediated by the viral...

Repositório Covid-19

18/09/2022

Anti-SARS-CoV-2 activity of targeted kinase inhibitors: Repurposing clinically available drugs for COVID-19 therapy

Abstract

Coronavirus disease 2019 (COVID-19) remains a major public health concern, and vaccine unavailability, hesitancy, or failure underscore the need...

Repositório Covid-19

17/09/2022

A review post-vaccination SARS-CoV-2 serological test: Method and antibody titer response

Serological tests for SARS-CoV-2 specific antibodies can used for public health surveillance and vaccine development.•

Repositório Covid-19

17/09/2022

Comparable Outcomes for Bebtelovimab and Ritonavir-Boosted Nirmatrelvir Treatment in High-Risk Patients With Coronavirus Disease-2019 During Severe Acute Respiratory Syndrome Coronavirus 2 BA.2 Omicron Epoch

Abstract

The effectiveness of bebtelovimab in real-world settings has not been assessed. In this retrospective cohort study of 3607 high-risk...

Repositório Covid-19

17/09/2022

A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant

Abstract

The recently emerged Omicron (B.1.1.529) variant has rapidly surpassed Delta to become the predominant circulating SARS-CoV-2 variant, given the...

Repositório Covid-19