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Repositório Covid-19

07/03/2022

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

There is strong evidence of brain-related abnormalities in COVID-191,2,3,4,5,6,7,8,9,10,11,12,13. However, it remains unknown whether the impact of SARS-CoV-2 infection can...

07/03/2022

Antimicrobial peptides: A plausible approach for COVID-19 treatment

Coronavirus disease 2019 (COVID-19), which emerged as a major public health threat, has affected >400 million people globally leading to...

07/03/2022

Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern

Neutralizing antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are useful for patients’ treatment of the coronavirus disease...

07/03/2022

When RING finger family proteins meet SARS-CoV-2

The pandemic coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently the most formidable...

07/03/2022

Clinical frailty, and not features of acute infection, is associated with late mortality in COVID-19: a retrospective cohort study

Coronavirus disease 2019 (COVID-19) is associated with excess mortality after hospital discharge. Identification of patients at increased risk of death...

03/03/2022

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

The identification of the Omicron (B.1.1.529.1 or BA.1) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Botswana in...

02/03/2022

Population Immunity and Covid-19 Severity with Omicron Variant in South Africa

The B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified on November 25, 2021, in...

02/03/2022

Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant

A rapid increase in coronavirus disease 2019 (Covid-19) cases due to the omicron (B.1.1.529) variant of severe acute respiratory syndrome...

01/03/2022

The Anti-Coronavirus Therapies (ACT) Trials: Design, Baseline Characteristics, and Challenges

Effective treatments for COVID-19 are urgently needed, but conducting randomized trials during the pandemic has been challenging.

01/03/2022

Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic is currently the major challenge to global public health. Two proteases,...

28/02/2022

Optimizing peptide inhibitors of SARS-Cov-2 nsp10/nsp16 methyltransferase predicted through molecular simulation and machine learning

Coronaviruses, including the recent pandemic strain SARS-Cov-2, use a multifunctional 2′-O-methyltransferase (2′-O-MTase) to restrict the host defense mechanism and to...

24/02/2022

Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis

The infection–fatality ratio (IFR) is a metric that quantifies the likelihood of an individual dying once infected with a pathogen....

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