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Notícias

29/07/2021

Antiviral drugs for coronavirus disease 2019 (COVID-19): a systematic review with network meta-analysis

To better inform clinical practice, we summarized the findings from randomized controlled trials (RCTs) of antivirals for COVID-19.

Repositório Covid-19
29/07/2021

Topological network based drug repurposing for coronavirus 2019

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has become the current health concern and...

Repositório Covid-19
29/07/2021

Synthesis and Identification of Novel Potential Molecules Against COVID-19 Main Protease Through Structure-Guided Virtual Screening Approach

The novel coronavirus disease that arises in the end of 2019 (COVID-19) in Wuhan, China, has rapidly spread over the...

Repositório Covid-19
29/07/2021

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global...

Repositório Covid-19
29/07/2021

A Novel Therapeutic Peptide Blocks SARS-CoV-2 Spike Protein Binding with Host Cell ACE2 Receptor

Coronavirus disease 2019 is a novel disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus. It was first...

Repositório Covid-19
29/07/2021

Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia

The efficacy and safety of tofacitinib, a Janus kinase inhibitor, in patients who are hospitalized with coronavirus disease 2019 (Covid-19)...

Repositório Covid-19
28/07/2021

Abbreviated Profile of Drugs (APOD): modeling drug safety profiles to prioritize investigational COVID-19 treatments

Safe and effective oral formulation of a drug, that is easy to store, transport, and administer, is imperative to reach...

Repositório Covid-19
28/07/2021

Potential protective role of the anti-PD-1 blockade against SARS-CoV-2 infection

The outbreak of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, in December 2019, and its global dissemination...

Repositório Covid-19
28/07/2021

Rapid and stable mobilization of CD8<sup>+</sup> T cells by SARS-CoV-2 mRNA vaccine

SARS-CoV-2 spike mRNA vaccines1,2,3 mediate protection from severe disease as early as ten days after prime vaccination3, when neutralizing antibodies...

Repositório Covid-19
28/07/2021

Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort

The presence of antiphospholipid antibodies was shown to be associated with thrombosis in coronavirus disease 2019 (COVID-19) patients. Recently, according...

Repositório Covid-19
28/07/2021

In-silico study of peptide-protein interaction of antimicrobial peptides potentially targeting SARS and SARS-CoV-2 nucleocapsid protein

This study is an attempt to find a suitable therapy using antimicrobial peptides (AMPs) by identifying peptide-protein interaction of AMPs...

Repositório Covid-19
28/07/2021

Nortec Química é líder nacional na fabricação de IFAs

Nortec Química é a maior fabricante de Insumos Farmacêuticos Ativos (IFAs) da
América Latina e tem reconhecido papel no...

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